Assessment2: Assignment (20%), Part A Assignment Part A Due Date: 18 Sept (8am) Length: ~1,000 words METABOLIC DISORDER Adenosine monophosphate deaminase 1 deficiency The Assignment integrates regulatory aspects of metabolism, enhancing lecture and laboratory activity to enable students to understand the role Research, Diagnostic, Treatment and Policy sectors rely on biochemistry (WIL). Task Address the current Research (R), Diagnosis (D), Treatment (T) and Policy (P) for the metabolic disorder Adenosine monophosphate deaminase 1 deficiency You should include a brief outline of the analysis method(s) used to detect or confirm the condition, from the topic list provided. Research will address the current research, published in scientific journals, regarding the topic or condition. Diagnosis will address the current diagnostics applied to the topic or condition. Treatment will address the current treatment options relevant to the topic or condition. Policy will address the current policies/legislation (federal, state or international) relevant to the topic or condition (e.g. adverse health outcomes or legislation for drug use). Criteria (PART A ONLY) You will be assessed on the following: The Assignment must use the Headings below and address the following: 1. Overview Identify the name(s), class and structure of the ‘Metabolic Disorder’ (Assignment Part A) and ‘Metabolic Manipulator’ (Assignment Part B) molecule and contextualize the intracellular metabolic biochemical pathways they affect (i.e. Protein, Carbohydrate and/or Lipid). Briefly outline the effect(s) the Disorder (Part A) and Manipulator (Part B) has on the organism locally (i.e. specific cells or tissue) and/or as a whole (i.e. the whole organism). Identify the Substrates/Precursors and the biochemical steps to produce the Disorder (Part A) and Manipulator (Part B) (i.e. parent molecule, key enzymes & cofactors involved in synthesis) and describe the transport, halflife, receptor activation and fate following action Disorder (Part A) effect, and Manipulator (Part B) degradation within the cell/organism. Describe the biochemical pathway(s) (i.e. Protein, Carbohydrate and/or Lipid), the selected Disorder (Part A) and Manipulator (Part B) alters, including key enzymes/cofactors and intermediates directly affected. 2. Research Describe the most recent research (published scientific article(s)) effort pertaining to the Disorder (Part A) and Manipulator (Part B). This may include, but not limited to, characterization of metabolic status, biochemical pathways, receptors and signal transduction within cells or tissue and the identification of potential therapeutic(s). 3. Diagnosis Identify the disease state(s)/or consequence(s) of the Disorder (Part A) and Manipulator (Part B) that arise if there is a genetic defect (Part A) or chemical perturbation (Part B) in the metabolic/biosynthetic pathway of target cells/tissues. 4. Treatment Describe the current treatment(s)/strategy(ies), approved for use, to overcome the disease state as a consequence of Disorder (Part A) and Manipulator (Part B). Comment on, with the aid of statistical information, the change in prognosis as a consequence of treatment. 5. Policy Outline the current policies/legislation (federal, state or international) relevant to the Disorder (Part A) and Manipulator (Part B) (e.g. adverse health outcomes or legislation for therapeutic use). Report Format. Diagrams maybe used (with appropriate references). The report should be in 12pt font, ~1,000 words (for each Part A & Part B), with Vancouver referencing format (labelled as superscript numbers throughout the text and identified in the References, Website(s) should include accession dates). Note: References and diagram/legends are not included in the word count.