`Importance and implications of antioxidants and oxidative stress in gene regulation of neurodegenerative disorders.
Information about the article content.
Oxidative stress is typically defined as an imbalance between the production/accumulation of reactive oxygen species (ROS) and antioxidant defenses to remove these reactive products from the biological system. ROS are oxygen-derivatives with an uneven number of electrons, which causes unintentional reaction with other molecules in the system, potentially leading to a number of deleterious effects including DNA damage, aging and cancer. Several antioxidant compounds, like vitamin E, flavonoids and polyphenols, were exploited for their ability to neutralize these reactive products, and hence used to treat various pathological conditions ranging from inflammation to cancer. Cell signaling and gene regulation are the fundamental activities of the cell to control the transfer of genetic information from a gene to a protein throughout its life. Regulating the expression of various antioxidant genes at precise times by the biological system is exceedingly important to overcome the toxic effects of oxidative stress. Therefore, understanding the interaction between oxidative stress, antioxidants, sand gene regulation in physiological as well as in pathological conditions is essential for the prevention and treatment of oxidative-stress-related conditions. The scope of this REVIEW PAPER shall cover a wide range of original and review articles aimed at exploring various aspects of oxidative stress, antioxidants and gene regulation in NEURODEGENERATIVE DISORDER.
Must contain molecular mechanism of gene regulation.
It would be better to add therapeutic approach as one head line.